Research from Tianjin University of Science and Technology in China has delved into the therapeutic potential of polysaccharides extracted from purple sweet potatoes (PSP) for treating ethanol-induced gastric ulcers in mice. The study demonstrated that PSP significantly reduced stomach acidity and pepsin activity, key factors in ulcer formation, and decreased the gastric ulcer index. The investigation into PSP's mechanism revealed a decrease in pro-inflammatory cytokines (TNF-α, IL-1β, IL-6) and an increase in the anti-inflammatory cytokine IL-10, indicating a balancing effect on the immune system.
Furthermore, PSP was found to enhance the body's immune defense by increasing levels of immunoglobulins IgM and IgG, complements C3 and C4, the activity of peritoneal macrophages, and the expression of CD4+/CD8+ lymphocyte subsets in the spleen. The study linked these effects to the activation of the PI3K/Akt/Rheb/mTOR signaling pathway, suggesting PSP's role in improving cellular functions and stress responses, essential for protecting the gastric mucosa.
This research aligns with other studies exploring natural compounds for gastric ulcer treatment, underscoring the potential of natural substances in offering effective alternatives to traditional ulcer medications. The findings contribute to the understanding of PSP's clinical implications for human health, marking a significant advancement in the search for novel ulcer treatments.
Source: naturalsciencenews.com